Abstract |
The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury compared with wild-type C57BL/6 littermates. This work further implicates the complement system as a participant in secondary progression of brain damage after head trauma and provides a strong rationale for future studies of posttraumatic pharmacologic complement inhibition.
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Authors | Mario Rancan, Maria C Morganti-Kossmann, Scott R Barnum, Silvia Saft, Oliver I Schmidt, Wolfgang Ertel, Philip F Stahel |
Journal | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
(J Cereb Blood Flow Metab)
Vol. 23
Issue 9
Pg. 1070-4
(Sep 2003)
ISSN: 0271-678X [Print] United States |
PMID | 12973023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cr1l protein, mouse
- Neuroprotective Agents
- Receptors, Complement
- Receptors, Complement 3b
- Complement System Proteins
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Topics |
- Animals
- Behavior, Animal
(physiology)
- Blood-Brain Barrier
(physiology)
- Brain
(pathology, physiopathology)
- Central Nervous System
(immunology)
- Complement Activation
- Complement System Proteins
(immunology)
- Head Injuries, Closed
(immunology, pathology, physiopathology)
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Neuroprotective Agents
(metabolism)
- Receptors, Complement
(genetics, metabolism)
- Receptors, Complement 3b
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