Vascular effects of step I diet in hypercholesterolemic patients with coronary artery disease.

Abstract

We administered a step I diet to 50 hypercholesterolemic patients with coronary artery disease during 12 weeks. Compared with baseline, the step I diet significantly changed lipoprotein levels, significantly improved the percent flow-mediated dilation response to hyperemia by 32 +/- 7% (p <0.001), increased plasma levels of nitrate by 45 +/- 12% (p = 0.013), and lowered plasma levels of malondialdehyde by 7 +/- 4% (p = 0.011). However, the step I diet did not significantly change serologic markers of inflammation, plaque stability, and thrombosis. Step I diet therapy improved endothelium-dependent vasodilation with an increase in plasma nitrogen oxide and a decrease in oxidant stress in hypercholesterolemic patients with coronary artery disease.

• Authors: Kwang Kon Koh, Jeong Yeal Ahn, Yu Mi Choi, Seung Hwan Han, Dae Sung Kim, Hyung Sik Kim, Tae Hoon Ahn, In Suck Choi, Eak Kyun Shin
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 92 Issue 6 Pg. 708-10 (Sep 15 2003) ISSN: 0002-9149 [Print] United States
• PMID: 12972113 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Inflammation Mediators
• Lipoproteins
• Nitrates
• Malondialdehyde

Topics

• Aged
• Coronary Artery Disease (blood, diet therapy, physiopathology)
• Coronary Circulation (drug effects, physiology)
• Endothelium, Vascular (drug effects, physiology)
• Female
• Humans
• Hypercholesterolemia (blood, diet therapy, physiopathology)
• Inflammation Mediators (blood)
• Lipoproteins (blood, drug effects)
• Male
• Malondialdehyde (blood)
• Middle Aged
• Nitrates (blood)
• Vasodilation (drug effects, physiology)
• Vasomotor System (drug effects, physiopathology)