Abstract | BACKGROUND AND OBJECTIVES: DESIGN AND METHODS: We measured ADAMTS-13 and VWF ( antigen, ristocetin cofactor activity, collagen binding, multimeric structure) in 17 pregnant women during HELLP syndrome and after 6 months during clinical remission. Controls were 25 healthy pregnant women and 50 healthy non-pregnant women. RESULTS: All the women with HELLP syndrome had lower plasma levels of ADAMTS-13 activity (median and range: 31%, 12-43) than did the healthy pregnant (71%, 48-105) and non-pregnant women (101%, 45-152); the reduced levels returned to normal on remission (115%, 90-170). Reduced levels were not due to the presence of inactivating autoantibodies and in no case was the protease undetectable in plasma. Ultralarge VWF multimers were not present in plasma, the levels of VWF were higher than in normal pregnancy. INTERPRETATION AND CONCLUSIONS:
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Authors | Antonella Lattuada, Edoardo Rossi, Cinzia Calzarossa, Rosaria Candolfi, Pier Mannuccio Mannucci |
Journal | Haematologica
(Haematologica)
Vol. 88
Issue 9
Pg. 1029-34
(Sep 2003)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 12969811
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- von Willebrand Factor
- ADAM Proteins
- Metalloendopeptidases
- ADAMTS13 Protein
- ADAMTS13 protein, human
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Topics |
- ADAM Proteins
- ADAMTS13 Protein
- Adult
- Autoantibodies
(blood)
- Female
- HELLP Syndrome
(blood, complications)
- Humans
- Metalloendopeptidases
(blood, deficiency, immunology)
- Pregnancy
- Pregnancy Complications, Hematologic
(blood, enzymology)
- Purpura, Thrombotic Thrombocytopenic
(blood, complications)
- von Willebrand Factor
(metabolism)
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