High levels of interleukin-1 in patients with endemic pemphigus foliaceus.

Abstract

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.

• Authors: Denise Bertulucci Rocha-Rodrigues, Giovana Paschoini, Sanivia Aparecida Lima Pereira, Marlene Antonia dos Reis, Vicente de Paula Antunes Teixeira, Virmondes Rodrigues Júnior
• Journal: Clinical and diagnostic laboratory immunology (Clin Diagn Lab Immunol) Vol. 10 Issue 5 Pg. 741-3 (Sep 2003) ISSN: 1071-412X [Print] United States
• PMID: 12965897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Interleukin-1
• Interleukin-5
• Tumor Necrosis Factor-alpha
• Interferon-gamma

Topics

• Autoimmune Diseases (metabolism)
• Cytokines (biosynthesis)
• Humans
• Interferon-gamma (biosynthesis)
• Interleukin-1 (biosynthesis)
• Interleukin-5 (biosynthesis)
• Leukocytes, Mononuclear (metabolism)
• Pemphigus (metabolism)
• Th2 Cells (immunology, metabolism)
• Tumor Necrosis Factor-alpha (biosynthesis)