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[Contrast-enhanced MR angiography of the arterial and portovenous system of the liver with varying concentrations of contrast medium].

AbstractPURPOSE:
To evaluate the diagnostic value of a higher concentrated contrast medium (gadobutrol) for contrast-enhanced MRA of the hepatic arteries and portovenous system.
MATERIALS AND METHODS:
The examinations were performed on a 1.5-Tesla whole body imaging system (Magnetom Symphony Quantum, Siemens) with a 30-mTesla/m gradient field strength using a phased-array body coil. A 3D FLASH sequence (TR/TE/FA 3.88 ms/1.44 ms/25(3)) was used imaging the hepatic arteries and portovenous system after determination of the circulation time. The study included 50 patients, with 25 patients (group 1) injected with 0.2 mmol Gd-GTPA/kg body weight and 25 patients (group 2) injected with 0.1 mmol gadobutrol/kg body weight. The signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) were calculated for both groups. The image quality was graded by three radiologists on a 5-point scale.
RESULTS:
The highest SNR was measured in group 1, with no statistically significant differences of the SNR in the abdominal aortal, coeliac trunk and common hepatic artery. CNR was also similar in both groups. Likewise, portal, superior mesenteric and splenic veins showed no statistically significant differences. All cases were found to have a good image quality.
CONCLUSION:
For MRA of the hepatic arteries and the portal veins, the higher concentrated Gd-DTPA contrast medium gadobutrol can be used at half the dosage recommended for the standard Gd-DTPA contrast medium.
AuthorsR Vosshenrich, B Engeroff, S Obenauer, E Grabbe
JournalRoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (Rofo) Vol. 175 Issue 9 Pg. 1239-43 (Sep 2003) ISSN: 1438-9029 [Print] Germany
Vernacular TitleKontrastmittel-gestützte 3D-MR-Angiographie des arteriellen und portalvenösen Gefässsystems der Leber mit unterschiedlicher KM-Konzentration.
PMID12964080 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Contrast Media
  • Organometallic Compounds
  • gadobutrol
  • Gadolinium
  • Gadolinium DTPA
Topics
  • Adult
  • Aged
  • Contrast Media (administration & dosage)
  • Data Interpretation, Statistical
  • Female
  • Gadolinium (administration & dosage)
  • Gadolinium DTPA (administration & dosage)
  • Hepatic Artery (anatomy & histology)
  • Humans
  • Liver Transplantation
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Organometallic Compounds (administration & dosage)
  • Portal Vein (anatomy & histology)

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