| Abstract | The effect of Dehydroleucodine (DhL) on gastric acid secretion in rats was investigated at a dose of 40 mg/kg, while its anti-inflammatory effect was investigated in two experimental models: arthritis induced by Freund's adjuvant carrageenan- and cotton pellet-induced granuloma. DhL did not inhibit gastric acid secretion, suggesting that its anti-ulcerogenic effect can be attributed to its action on the mucosa defense factors. On the other hand, DhL inhibited both chronic and acute adjuvant carrageenan-induced inflammation phases, being most effective in the chronic phase. In the granuloma test, DhL also inhibited inflammation. It is suggested that the anti-inflammatory activity of DhL may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines. |
| Authors | T Guardia, A O Juarez, E Guerreiro, J A Guzmán, L Pelzer
(Affiliation: Pharmacology Unit, Department of Pharmacy, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Chacabuco and Pedernera, C.P. 5.700, San Luis, Argentina. tguardia at unsl.edu.ar)
|
| Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 88
Issue 2-3
Pg. 195-8
(Oct 2003)
ISSN: 0378-8741 Ireland |
| PMID | 12963142
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Lactones
- Plant Extracts
- Sesquiterpenes
- dehydroleucodine
|
| Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(isolation & purification, pharmacology)
- Artemisia
(chemistry)
- Disease Models, Animal
- Female
- Gastric Acid
(secretion)
- Inflammation
(chemically induced, drug therapy)
- Lactones
(isolation & purification, pharmacology)
- Male
- Plant Components, Aerial
(chemistry)
- Plant Extracts
(pharmacology)
- Rats
- Rats, Wistar
- Sesquiterpenes
(isolation & purification, pharmacology)
|
