A model of allergic nasal congestion in dogs sensitized to ragweed.

Abstract

BACKGROUND:

Acoustic rhinometry is a noninvasive method that uses sound waves to measure dimensions of the nasal cavity.

METHODS:

In this study, nasal patency was measured by acoustic rhinometry in allergic Beagle dogs sensitized to ragweed allergen. Ragweed (0.03-0.3%) or vehicle were administered intranasally in isoflurane-anesthetized dogs.

RESULTS:

The instillation of ragweed caused a dose-related decrease in nasal cavity volume and minimal cross-sectional area (Amin) without adverse systemic effects. Nasal cavity volume and Amin decreased within 30 minutes after instillation of the highest ragweed dose by 35.1 +/- 6.0% and 66.4 +/- 13.8%, respectively, and persisted for at least 90 minutes. Oral administration of alpha-adrenergic agonist, d-pseudoephedrine (3 mg/kg), or histamine H1 antagonist chlorpheniramine (10 mg/ kg) blocked the ragweed-induced nasal congestion.

CONCLUSION:

These results suggest that the canine model may be used to study upper-airway diseases such as allergic rhinitis and to evaluate the pharmacologic activity of nasal decongestants.

• Authors: Karin Rudolph, David E Bice, John A Hey, Robbie L McLeod
• Journal: American journal of rhinology (Am J Rhinol) 2003 Jul-Aug Vol. 17 Issue 4 Pg. 227-32 ISSN: 1050-6586 [Print] United States
• PMID: 12962193 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic alpha-Agonists
• Anti-Allergic Agents
• Histamine H1 Antagonists
• Nasal Decongestants
• Chlorpheniramine
• Ephedrine
• Oxygen

Topics

• Adrenergic alpha-Agonists (pharmacology)
• Airway Resistance (drug effects)
• Ambrosia
• Animals
• Anti-Allergic Agents (pharmacology)
• Blood Pressure (drug effects)
• Body Temperature (drug effects)
• Chlorpheniramine (pharmacology)
• Disease Models, Animal
• Dogs
• Ephedrine (pharmacology)
• Heart Rate (drug effects)
• Histamine H1 Antagonists (pharmacology)
• Nasal Decongestants (pharmacology)
• Nasal Obstruction (chemically induced, drug therapy, physiopathology)
• Oxygen (blood)
• Rhinometry, Acoustic (methods)