Lipopolysaccharide and TNFalpha regulate the expression of GDNF, neurturin and their receptors.

Abstract	Inflammatory processes in the brain may trigger specific neuroprotective responses in glial cells. Here, we show that bacterial lipopolysaccharide strongly up-regulates glial derived neurotrophic factor (GDNF) mRNA while it down-regulates that of neurturin. Tumor necrosis factor alpha (TNFalpha) had different effects since it stimulated neurturin expression without enhancing GDNF mRNA. Interestingly, both lipopolysaccharide and TNFalpha triggered a significant decrease in the expression of the GDNF receptor, GFRalpha1, in glial cells. While the significance of such down-regulation during inflammatory processes remains to be characterised, the differential regulation of GDNF and neurturin following lipopolysaccharide and TNFalpha treatments suggest specific neuroprotective responses of glial cells in case of bacterial infection, trauma, transplantation or neurodegenerative diseases.
Authors	Séverine Rémy, Philippe Naveilhan, Vincent Paillé, Philippe Brachet, Isabelle Neveu
Journal	Neuroreport (Neuroreport) Vol. 14 Issue 11 Pg. 1529-34 (Aug 06 2003) ISSN: 0959-4965 [Print] England
PMID	12960779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Gdnf protein, rat Glial Cell Line-Derived Neurotrophic Factor Glial Cell Line-Derived Neurotrophic Factor Receptors Lipopolysaccharides Nerve Growth Factors Neurturin Nrtn protein, rat Proto-Oncogene Proteins RNA, Messenger Tumor Necrosis Factor-alpha Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases
Topics	Animals Cells, Cultured Glial Cell Line-Derived Neurotrophic Factor Glial Cell Line-Derived Neurotrophic Factor Receptors Lipopolysaccharides (pharmacology) Nerve Growth Factors (biosynthesis, genetics) Neuroglia (drug effects, metabolism) Neurturin Nuclease Protection Assays Proto-Oncogene Proteins (biosynthesis, genetics) Proto-Oncogene Proteins c-ret RNA, Messenger (biosynthesis, genetics) Rats Receptor Protein-Tyrosine Kinases (biosynthesis, genetics) Tumor Necrosis Factor-alpha (pharmacology)

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