Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog.

Abstract	Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body weight, and thermoregulation. Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue. This dose of capsiate did not change serum triiodothyronine or thyroxine levels. A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle. These results suggest that UCP1 and UCP2 may contribute to the promotion of energy metabolism by capsiate, but that thyroid hormones do not.
Authors	Yoriko Masuda, Satoshi Haramizu, Kasumi Oki, Koichiro Ohnuki, Tatsuo Watanabe, Susumu Yazawa, Teruo Kawada, Shu-ichi Hashizume, Tohru Fushiki
Journal	Journal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol (1985)) Vol. 95 Issue 6 Pg. 2408-15 (Dec 2003) ISSN: 8750-7587 [Print] United States
PMID	12959953 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carrier Proteins Gases Ion Channels Membrane Proteins Membrane Transport Proteins Mitochondrial Proteins Thyroid Hormones Ucp1 protein, mouse Ucp2 protein, mouse Ucp3 protein, mouse Uncoupling Protein 1 Uncoupling Protein 2 Uncoupling Protein 3 RNA capsiate Capsaicin
Topics	Adipose Tissue (drug effects) Adipose Tissue, Brown (metabolism) Animals Blotting, Western Capsaicin (analogs & derivatives, pharmacology) Carbohydrate Metabolism Carrier Proteins (biosynthesis, metabolism) Epididymis (metabolism) Gases (metabolism) Ion Channels Male Membrane Proteins (metabolism) Membrane Transport Proteins (biosynthesis) Mice Mitochondrial Proteins (biosynthesis) Muscle, Skeletal (metabolism) Organ Size (drug effects) Oxygen Consumption (drug effects) RNA (biosynthesis) Reverse Transcriptase Polymerase Chain Reaction Thyroid Hormones (blood) Uncoupling Protein 1 Uncoupling Protein 2 Uncoupling Protein 3 Up-Regulation (drug effects)

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