Abstract | BACKGROUND: METHODS: Twenty patients with moderate to severe COPD (age was [mean +/- standard deviation (SD)] 64 +/- 7 years, FEV1/FVC ratio was 45 +/- 11%) were randomized in a crossover, double-blind, placebo-controlled clinical trial to receive two puffs of either ipratropium bromide plus salbutamol (IB+S), IB+placebo (P), S+P, or P+P through metered dose inhalers (MDIs) daily over a 2-week period for each combination. At the end of each period, spirometry was obtained at baseline and 15, 30, 60, and 120 min after bronchodilator. Dyspnea was evaluated using a Borg scale during a 12-min walking test (12-MWT) performed at baseline and 120 min after MDIs use. In addition, the dyspnea component of the Chronic Respiratory Disease Questionnaire (CRDQ) and a diary of symptoms were used to evaluate this symptom. RESULTS: After 15 days of treatment, FEV1 improved significantly with all three combinations of MDIs containing bronchodilator agents. In comparison with placebo, significant improvement in dyspnea during 12-MWT was observed only when the combination of IB+S was used. No significant changes in CRDQ or patients' symptom diaries were observed with any combinations used. CONCLUSIONS: Combination of the two bronchodilators used in this study appears to alleviate perception of dyspnea more than use of either agent alone.
|
Authors | Raúl Sansores, Alejandra Ramírez-Vanegas, Carl Reddy, Roberto Mejía-Alfaro |
Journal | Archives of medical research
(Arch Med Res)
2003 Jul-Aug
Vol. 34
Issue 4
Pg. 292-7
ISSN: 0188-4409 [Print] United States |
PMID | 12957526
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Bronchodilator Agents
- Placebos
- Oxygen
|
Topics |
- Adult
- Aged
- Bronchodilator Agents
(therapeutic use)
- Clinical Trials as Topic
- Cross-Over Studies
- Dyspnea
(pathology)
- Exercise
- Female
- Humans
- Male
- Oxygen
(metabolism)
- Placebos
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Quality of Life
- Spirometry
(methods)
- Surveys and Questionnaires
- Time Factors
|