Abstract | AIMS/BACKGROUND: METHODS: RESULTS: Levels of liver enzymes and urea in serum, blood ammonia values, liver histology, stage of hepatic encephalopathy and survival were statistically significantly improved in TAA-intoxicated and HSS-treated rats compared to TAA-intoxicated and saline-treated ones. Furthermore, HSS ameliorated liver regenerative indices-- DNA biosynthesis, thymidine kinase activity and hepatocyte mitotic activity--in a statistically significant manner. CONCLUSIONS: Our data suggest the beneficial effect of HSS administration in this animal model of FHF and encephalopathy, supporting evidence for a possible use of HSS as supportive therapy, by increasing hepatocellular proliferation, in management of FHF.
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Authors | Alexandra P Margeli, Lila Papadimitriou, Sotirios Ninos, Evangelos Manolis, Michael G Mykoniatis, Stamatios E Theocharis |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 23
Issue 3
Pg. 171-8
(Jun 2003)
ISSN: 1478-3223 [Print] United States |
PMID | 12955880
(Publication Type: Journal Article)
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Chemical References |
- Growth Substances
- Intercellular Signaling Peptides and Proteins
- Mitogens
- Peptides
- Sulfur Compounds
- hepatic stimulator substance
- Thioacetamide
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Topics |
- Animals
- Growth Substances
(administration & dosage)
- Hepatic Encephalopathy
(chemically induced)
- Injections, Intraperitoneal
- Intercellular Signaling Peptides and Proteins
- Liver Failure
(chemically induced)
- Liver Regeneration
(drug effects)
- Male
- Mitogens
(administration & dosage)
- Models, Animal
- Peptides
(administration & dosage)
- Rats
- Rats, Wistar
- Sulfur Compounds
(adverse effects)
- Survival Analysis
- Thioacetamide
(adverse effects)
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