HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Myeloid/natural killer cell precursor acute leukemia accompanied by homozygous protein C deficiency.

Abstract
A patient with myeloid/natural killer (NK) cell precursor acute leukemia who was also homozygous for protein C deficiency was treated and showed a complete remission while he simultaneously received low molecular weight heparin. He presented with fever spikes, lymphadenopathy, and a bulky tumor of the anterior mediastinum. A bone marrow aspirate showed the infiltration of immature lymphoblastoid cells. The patient's diagnosis was determined to be myeloid/NK cell precursor acute leukemia by morphologic and immunophenotypic analysis (CD7(+)CD33(+)CD34(+)CD56(+)). The patient developed a thrombosis in his jugular vein on cannulation of the internal jugular vein. An examination of the serum levels and the activities of proteins C and S demonstrated a slight decrease in the protein C level but an undetectable protein C activity. The patient received the diagnosis of homozygous protein C deficiency, because both parents were found to have heterozygous protein C activity. Treatment of the patient's leukemia included induction chemotherapy (Ara-C and idarubicin) with concomitant administration of low molecular weight heparin for his homozygous protein C deficiency. He achieved a complete remission without expressing any thrombosis during the course of chemotherapy. To our knowledge, this is the first case ever described in which acute myeloid leukemia was complicated with homozygous protein C deficiency.
AuthorsTakashi Shimamoto, Akihiro Nakajima, Tomoko Katagiri, Yoshikazu Ito, Kazuma Ohyashiki
JournalInternational journal of hematology (Int J Hematol) Vol. 78 Issue 2 Pg. 149-53 (Aug 2003) ISSN: 0925-5710 [Print] Japan
PMID12953810 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Anticoagulants
  • Antimetabolites, Antineoplastic
  • Heparin, Low-Molecular-Weight
  • Cytarabine
  • Idarubicin
Topics
  • Acute Disease
  • Adult
  • Antibiotics, Antineoplastic (therapeutic use)
  • Anticoagulants (therapeutic use)
  • Antimetabolites, Antineoplastic (therapeutic use)
  • Cytarabine (therapeutic use)
  • Heparin, Low-Molecular-Weight (therapeutic use)
  • Homozygote
  • Humans
  • Idarubicin (therapeutic use)
  • Killer Cells, Natural (pathology)
  • Leukemia, Myeloid (complications, drug therapy, pathology)
  • Male
  • Myeloid Cells (pathology)
  • Neoplastic Stem Cells (pathology)
  • Pedigree
  • Protein C Deficiency (complications, drug therapy, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: