[Shoshin beriberi provoked by the inhalation of salbutamol].

Abstract

A 45-year-old male alcoholic with a deficient diet was given salbutamol for exertion-related dyspnoea. After inhalation, he presented with a severe dyspnoea, acrocyanosis, anuria and low blood pressure as well as a respiratory compensated lactate acidosis. Shoshin beriberi was suspected on clinical grounds. The low level of thiamine and the prompt recovery after thiamine repletion confirmed this diagnosis. Shoshin beriberi is an acute, cardiac form of beriberi, which can rapidly result in death due to cardiogenic shock and lactate acidosis. Adrenergic agents can cause a hyperdynamic circulation and thus aggravate the effects of a thiamine deficiency.

• Authors: J H Groeneveld, P H Geelhoed-Duijvestijn, R F Veldkamp, H J Baur
• Journal: Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 147 Issue 33 Pg. 1601-3 (Aug 16 2003) ISSN: 0028-2162 [Print] Netherlands
• Vernacular Title: Sjosjin-beriberi na inhalatie van salbutamol.
• PMID: 12951730 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Bronchodilator Agents
• Albuterol
• Thiamine

Topics

• Acidosis, Lactic (diagnosis, etiology)
• Acute Disease
• Administration, Inhalation
• Albuterol (administration & dosage, adverse effects)
• Beriberi (chemically induced, complications, diagnosis, drug therapy)
• Bronchodilator Agents (administration & dosage, adverse effects)
• Cardiac Output, Low (diagnosis, etiology)
• Humans
• Male
• Middle Aged
• Thiamine (therapeutic use)
• Thiamine Deficiency (complications, drug therapy)