Abstract | OBJECTIVES: A rat model was used to investigate the efficacy of linezolid, alone or in combination with levofloxacin and vancomycin, in the prevention of vascular prosthetic graft infection resulting from methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides. METHODS: Graft infections were established in the subcutaneous tissue of adult male Wistar rats by implantation of Dacron prostheses, followed by topical inoculation with S. epidermidis. The study comprised: one group without inoculation; one inoculated group without prophylaxis; six inoculated groups that received intraperitoneal linezolid (8 mg/kg), levofloxacin (7 mg/kg) or vancomycin (7 mg/kg) alone or in combination at the dosages mentioned above. Each group included 20 animals. The grafts were removed after 7 days and evaluated by quantitative culture. RESULTS: CONCLUSIONS:
Linezolid as perioperative prophylaxis can be useful for the prevention of graft infections caused by multiresistant staphylococcal strains.
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Authors | Andrea Giacometti, Roberto Ghiselli, Oscar Cirioni, Federico Mocchegiani, Fiorenza Orlando, Maria Simona Del Prete, Giuseppina D'Amato, Carmela Silvestri, Vittorio Saba, Giorgio Scalise |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 52
Issue 4
Pg. 724-6
(Oct 2003)
ISSN: 0305-7453 [Print] England |
PMID | 12951347
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acetamides
- Glycopeptides
- Oxazolidinones
- Levofloxacin
- Vancomycin
- Ofloxacin
- Linezolid
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Topics |
- Acetamides
(pharmacology, therapeutic use)
- Animals
- Antibiotic Prophylaxis
(methods)
- Drug Resistance, Bacterial
(drug effects, physiology)
- Drug Therapy, Combination
(pharmacology, therapeutic use)
- Glycopeptides
(pharmacology, therapeutic use)
- Graft Rejection
(drug therapy, microbiology)
- Levofloxacin
- Linezolid
- Male
- Microbial Sensitivity Tests
- Ofloxacin
(pharmacology, therapeutic use)
- Oxazolidinones
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Staphylococcal Infections
(drug therapy, microbiology)
- Staphylococcus epidermidis
(drug effects, growth & development)
- Vancomycin
(pharmacology, therapeutic use)
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