No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans.

Abstract	Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.
Authors	Kenji Nakata, Hiroshi Ujike, Yuji Tanaka, Manabu Takaki, Ayumu Sakai, Akira Nomura, Takeshi Katsu, Naohiko Uchida, Takaki Imamura, Yutaka Fujiwara, Takashi Hamamura, Shigetoshi Kuroda
Journal	Neuroscience letters (Neurosci Lett) Vol. 349 Issue 3 Pg. 171-4 (Oct 09 2003) ISSN: 0304-3940 [Print] Ireland
PMID	12951196 (Publication Type: Journal Article)
Chemical References	Intercellular Signaling Peptides and Proteins Nerve Tissue Proteins Proteins collapsin response mediator protein-2
Topics	Adult Aged Bipolar Disorder (enzymology, genetics) Case-Control Studies Chromosomes, Human, Pair 8 (genetics) DNA Mutational Analysis Female Gene Frequency (genetics) Genetic Linkage (genetics) Genetic Predisposition to Disease (genetics) Genotype Humans Intercellular Signaling Peptides and Proteins Japan Male Middle Aged Nerve Tissue Proteins (metabolism) Polymorphism, Genetic (genetics) Proteins (genetics, metabolism) Schizophrenia (enzymology, genetics)

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