Mutation and association analysis of the DAP-1 gene with schizophrenia.

Abstract

Glutamate dysfunction has been hypothesized to be involved in the pathophysiology of schizophrenia. The human homolog of Drosophila discs large protein (hDLG) and post-synaptic density-95-associated protein-1 (DAP-1) is one of the major proteins that are involved in intracellular signal transduction via N-methyl-d-aspartate receptors. In the present study 33 Japanese patients with schizophrenia were screened for mutations in the DAP-1 gene. A single nucleotide polymorphism was identified in the DAP-1 gene (1618A/G). A case-control study using a larger sample of unrelated patients and controls did not reveal a significant association between this polymorphism and schizophrenia. The results do not provide evidence that the DAP-1 gene is involved in vulnerability to schizophrenia.

• Authors: Shinsuke Aoyama, Osamu Shirakawa, Hisae Ono, Takeshi Hashimoto, Yasuo Kajimoto, Kiyoshi Maeda
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 57 Issue 5 Pg. 545-7 (Oct 2003) ISSN: 1323-1316 [Print] Australia
• PMID: 12950712 (Publication Type: Journal Article)

Chemical References

• DLGAP1 protein, human
• Nerve Tissue Proteins
• SAP90-PSD95 Associated Proteins
• DNA

Topics

• Case-Control Studies
• DNA (genetics)
• DNA Mutational Analysis
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Middle Aged
• Mutation
• Nerve Tissue Proteins (genetics)
• Polymerase Chain Reaction
• Polymorphism, Single-Stranded Conformational
• SAP90-PSD95 Associated Proteins
• Schizophrenia (genetics)