Patient with Kabuki syndrome and acute leukemia.

Abstract

Kabuki syndrome is a multiple congenital anomaly/mental retardation syndrome which often involves recurrent infections. There is cumulative evidence of an immunodeficiency in Kabuki patients. We report a 2-year-old girl with typical Kabuki syndrome, who developed acute lymphocytic leukemia. The patient showed low levels of immunoglobulins G and A and a history of recurrent infections, that might indicate an immunodeficiency leading to an increased susceptibility to cancer. The girl was treated according to BFM protocols adapted to the patient's impaired cardiac situation and severe underweight. She achieved continual complete remission. Classical and molecular cytogenetic analyzes did not detect any abnormality.

• Authors: Sabine Scherer, Ursel Theile, Vera Beyer, Rudolf Ferrari, Christiane Kreck, Manfred Rister
• Journal: American journal of medical genetics. Part A (Am J Med Genet A) Vol. 122A Issue 1 Pg. 76-9 (Sep 15 2003) ISSN: 1552-4825 [Print] United States
• PMID: 12949977 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2003 Wiley-Liss, Inc.

Topics

• Abnormalities, Multiple (genetics, physiopathology)
• Female
• Humans
• Infant
• Intellectual Disability (genetics, physiopathology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (physiopathology)