Abstract |
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 ( LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
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Authors | Vanessa L Ott, John C Cambier, John Kappler, Philippa Marrack, Bradley J Swanson |
Journal | Nature immunology
(Nat Immunol)
Vol. 4
Issue 10
Pg. 974-81
(Oct 2003)
ISSN: 1529-2908 [Print] United States |
PMID | 12949532
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hyaluronan Receptors
- Receptors, CCR5
- Receptors, Interleukin-2
- Receptors, Leukotriene B4
- Leukotriene B4
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Topics |
- Animals
- Base Sequence
- Chemotaxis, Leukocyte
(immunology)
- Female
- Hyaluronan Receptors
(genetics, immunology)
- Leukotriene B4
(biosynthesis, immunology)
- Male
- Mast Cells
(immunology, metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Oligonucleotide Array Sequence Analysis
- Receptors, CCR5
(genetics, immunology)
- Receptors, Interleukin-2
(genetics, immunology)
- Receptors, Leukotriene B4
(immunology)
- T-Lymphocyte Subsets
(immunology)
- T-Lymphocytes, Regulatory
(immunology)
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