Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
AuthorsVanessa L Ott, John C Cambier, John Kappler, Philippa Marrack, Bradley J Swanson
JournalNature immunology (Nat Immunol) Vol. 4 Issue 10 Pg. 974-81 (Oct 2003) ISSN: 1529-2908 [Print] United States
PMID12949532 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, CD44
  • Receptors, CCR5
  • Receptors, Interleukin-2
  • Receptors, Leukotriene B4
  • Leukotriene B4
  • Animals
  • Antigens, CD44 (genetics, immunology)
  • Base Sequence
  • Chemotaxis, Leukocyte (immunology)
  • Female
  • Leukotriene B4 (biosynthesis, immunology)
  • Male
  • Mast Cells (immunology, metabolism)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Molecular Sequence Data
  • Oligonucleotide Array Sequence Analysis
  • Receptors, CCR5 (genetics, immunology)
  • Receptors, Interleukin-2 (genetics, immunology)
  • Receptors, Leukotriene B4 (immunology)
  • T-Lymphocyte Subsets (immunology)
  • T-Lymphocytes, Regulatory (immunology)

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