Abstract |
Despite the proven efficacy of low-dose pamidronate in adults with osteoporosis, the efficacy of the low-dose regimen in children has not been studied. Pamidronate (1 mg/kg) was administered intravenously once every 3 months to 11 children with osteoporosis. Treatment was associated with reduced fracture rates and increased areal (BMD) and volumetric (BMAD) bone mineral density measured by dual energy X-ray absorptiometry (DXA). The mean annualized percent gain was 20.1 +/- 16.9 (4.7 to 59.1, n = 9) for spinal BMD and 15.1 +/- 18.1 (-11.0 to 40.2, n = 9) for spinal BMAD. Common adverse effects including fever, muscle aches, nausea and fatigue were self-limited and generally occurred only after the first infusion. Clinically significant hypocalcemia did not occur. Low-dose pamidronate appears promising in the treatment of childhood osteoporosis.
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Authors | Laura M Gandrud, Jennifer C Cheung, Mark W Daniels, Laura K Bachrach |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
2003 Jul-Aug
Vol. 16
Issue 6
Pg. 887-92
ISSN: 0334-018X [Print] Germany |
PMID | 12948302
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Diphosphonates
- Hormones
- Pamidronate
- Calcium
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Topics |
- Absorptiometry, Photon
- Adolescent
- Anti-Inflammatory Agents
(administration & dosage, adverse effects, therapeutic use)
- Bone Density
(drug effects)
- Calcium
(blood)
- Child
- Diphosphonates
(administration & dosage, adverse effects, therapeutic use)
- Female
- Fractures, Bone
(epidemiology, prevention & control)
- Growth
(drug effects)
- Hormones
(blood)
- Humans
- Injections, Intravenous
- Male
- Osteoporosis
(complications, drug therapy)
- Pamidronate
- Weight Gain
(drug effects)
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