Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.

Abstract

Afromosin [1] and soyasaponin I [2] isolated from Wistaria brachybotrys exhibited remarkable inhibitory effects on mouse skin tumor promotion, and afromosin also exhibited a significant inhibitory effect on pulmonary tumor promotion. The combined effects of these compounds on the two-stage skin carcinogenesis were also examined, and it was concluded that the combination of 1 with 2 enhanced the inhibitory effect.

• Authors: T Konoshima, M Kokumai, M Kozuka, H Tokuda, H Nishino, A Iwashima
• Journal: Journal of natural products (J Nat Prod) Vol. 55 Issue 12 Pg. 1776-8 (Dec 1992) ISSN: 0163-3864 [Print] United States
• PMID: 1294698 (Publication Type: Journal Article)

Chemical References

• Anticarcinogenic Agents
• Isoflavones
• Saponins
• soyasaponin I
• afromosin
• 9,10-Dimethyl-1,2-benzanthracene
• Oleanolic Acid
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene (antagonists & inhibitors, toxicity)
• Animals
• Anticarcinogenic Agents (isolation & purification, pharmacology)
• Cocarcinogenesis
• Female
• Isoflavones (isolation & purification, pharmacology)
• Lung Neoplasms (chemically induced, prevention & control)
• Mice
• Mice, Inbred ICR
• Oleanolic Acid (analogs & derivatives)
• Plants, Medicinal (chemistry)
• Saponins (isolation & purification, pharmacology)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (toxicity)