[Syst-Eur study: analysis of the benefits of nitrendipine in hypertensive type 2 diabetics].

Abstract

OBJECTIVE:

To demonstrate that nitrendipine reduces the morbimortality of elderly type 2 diabetic patients with isolated systolic hypertension.

METHODOLOGY:

New analyses of the 547 type 2 diabetics patients with isolated systolic hypertension (160 < PAS < 219: PAD < 95 mmHg), included in the international Syst-Eur trial, with an average follow-up of 2 years. Type 2 diabetes is defined according to the 1998 WHO guidelines: a fasting glycemia level, > or = 126 mg/dl and a post-prandial glycemia > or = 200 mg/dl.

RESULTS:

Nitrendipine as a first line treatment provides better protection against fatal and no fatal cardiovascular events compared with placebo. The risk reduction of cardiovascular mortality is 70% (IC 95%: -89/-18; p = 0.01), 61% (IC 95%: -79/-29; p = 0.001) for fatal and non fatal cardiovascular events, 65% (IC 95%: -86/-10; p = 0.02) for fatal and non fatal stroke and 61% (IC 95%: -83/-11; p = 0.02) for fatal and non fatal cardiac events. Therefore, nitrendipine as a first line treatment, reduces significantly cardiovascular events, strokes and cardiac events (p = 0.02; p = 0.007; p = 0.009; p = 0.04, respectively) in the diabetic group versus the no diabetic group, with a big trend (p = 0.07) for total mortality. Nitrendipine was well tolerated by this population.

CONCLUSION:

These results demonstrate the benefits of nitrendipine as a first line treatment in type 2 diabetic hypertensive patients.

• Authors: M Safar, L Thijs, J A Staessen
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) 2003 Jul-Aug Vol. 96 Issue 7-8 Pg. 768-71 ISSN: 0003-9683 [Print] France
• Vernacular Title: Etude Syst-Eur: analyse des bénéfices de la nitrendipine chez les patients diabétiques de type 2 hypertendus.
• PMID: 12945220 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Antihypertensive Agents
• Hypoglycemic Agents
• Insulin
• Nitrendipine

Topics

• Antihypertensive Agents (pharmacology)
• Cardiovascular Diseases (etiology, prevention & control)
• Diabetes Mellitus, Type 2 (complications)
• Humans
• Hyperglycemia (complications, etiology)
• Hypertension (complications, drug therapy)
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Nitrendipine (pharmacology)
• Risk Factors
• Treatment Outcome