Bioactive flavonoids of Tanacetum parthenium revisited.

Abstract

Bio-guided fractionation of an extract from Tanacetum parthenium showing activity as mitotic blocker allowed the isolation and identification of santin 3, jaceidin 2 and centaureidin 1. The latter two closely related flavonols, which, to the best of our knowledge, are isolated here together for the first time, form a mixture difficult to resolve and which is probably the reason for the confusion in the literature regarding their occurrence. Centaureidin 1 had an IC50 of 1 microM while jaceidin 2 and santin 3 were 200 times less active.

• Authors: Christophe Long, Pierre Sauleau, Bruno David, Catherine Lavaud, Valérie Cassabois, Frédéric Ausseil, Georges Massiot
• Journal: Phytochemistry (Phytochemistry) Vol. 64 Issue 2 Pg. 567-9 (Sep 2003) ISSN: 0031-9422 [Print] England
• PMID: 12943776 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Flavonoids
• Flavonols
• Plant Extracts
• santin
• centaureidin

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Chemical Fractionation (methods)
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Flavonols (chemistry, isolation & purification, pharmacology)
• Inhibitory Concentration 50
• Mitosis (drug effects)
• Plant Extracts (chemistry)
• Tanacetum parthenium (chemistry)