Abstract |
Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R,3R,8R,9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.
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Authors | A Takahashi, T Endo, S Nozoe |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 40
Issue 12
Pg. 3181-4
(Dec 1992)
ISSN: 0009-2363 [Print] Japan |
PMID | 1294319
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alkynes
- Antineoplastic Agents, Phytogenic
- Cytotoxins
- Epoxy Compounds
- repandiol
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Topics |
- Alkynes
(chemical synthesis, isolation & purification, toxicity)
- Animals
- Antineoplastic Agents, Phytogenic
- Basidiomycota
(chemistry)
- Cell Line
- Cytotoxins
(chemical synthesis, isolation & purification, toxicity)
- Drug Screening Assays, Antitumor
- Epoxy Compounds
(chemical synthesis, isolation & purification, toxicity)
- Humans
- Stereoisomerism
- Tumor Cells, Cultured
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