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Repandiol, a new cytotoxic diepoxide from the mushrooms Hydnum repandum and H. repandum var. album.

Abstract
Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R,3R,8R,9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.
AuthorsA Takahashi, T Endo, S Nozoe
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 40 Issue 12 Pg. 3181-4 (Dec 1992) ISSN: 0009-2363 [Print] Japan
PMID1294319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkynes
  • Antineoplastic Agents, Phytogenic
  • Cytotoxins
  • Epoxy Compounds
  • repandiol
Topics
  • Alkynes (chemical synthesis, isolation & purification, toxicity)
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Basidiomycota (chemistry)
  • Cell Line
  • Cytotoxins (chemical synthesis, isolation & purification, toxicity)
  • Drug Screening Assays, Antitumor
  • Epoxy Compounds (chemical synthesis, isolation & purification, toxicity)
  • Humans
  • Stereoisomerism
  • Tumor Cells, Cultured

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