HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Evaluation of efficacy of cyproterone acetate monotherapy in prostatic cancer].

Abstract
The trial conducted in the Primorsk Regional Cancer Hospital of Vladivostok and P. A. Herzen Moscow Research Cancer Institute studied effectiveness and tolerance of cyproteron acetate (CA) monotherapy and maximal androgenic block (MAB) (CA + surgical or CA + drug castration). A total of 70 patients with localized, locally advanced and generalized prostatic cancer entered the trial. They were divided into three groups: group 1 (54.3%) patients received CA monotherapy--300 mg/day, group 2 (27.1% patients) was exposed to MAB by surgical castration and received CA in a dose 200 mg/day, group 3 (18.6% patients) were exposed to MAB by drug castration and received 200 mg/day CA. The results obtained show that CA monotherapy and MAB have similar effectiveness in favourable prognostic signs. CA monotherapy was less toxic than CA combination with castratio.
AuthorsL I Gurina, S V Iudin, I G Rusakov, A A Bystrov
JournalUrologiia (Moscow, Russia : 1999) (Urologiia) 2003 Jul-Aug Issue 4 Pg. 25-30 ISSN: 1728-2985 [Print] Russia (Federation)
Vernacular TitleOtsenka éffektivnosti monoterapii raka predstatel'noĭ zhelezy s ispol'zovaniem tsiproterona atseta.
PMID12942722 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Androgen Antagonists
  • Antineoplastic Agents
  • Cyproterone Acetate
Topics
  • Aged
  • Androgen Antagonists (therapeutic use)
  • Antineoplastic Agents (therapeutic use)
  • Combined Modality Therapy
  • Cyproterone Acetate (therapeutic use)
  • Drug Tolerance
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Orchiectomy
  • Prostatic Neoplasms (drug therapy, surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: