Abstract |
Caerulein-induced acute pancreatitis was studied in rats. Consistent with this type of acute pancreatitis morphological ( edema, leukocytic infiltration and acinar cell vaculization) and biochemical (increase in pancreatic protein content. PAF release and serum amylase) changes developed 5 hours after caerulein administration. In addition increase in pancreatic weight and decrease in pancreatic blood flow were noticed. PAF administration caused pancreatic damage similar in some parameters to caerulein-induced pancreatitis, along with reduction of pancreatic blood flow, increase in pancreatic protein content, and serum amylase. TCV-309, a selective PAF antagonist, administered prior to caerulein and/or PAF, reduced caerulein-induced pancreatitis and prevented PAF-induced pancreatitis. Results of our present studies indicate the crucial role of PAF in pathogenesis of experimental acute pancreatitis.
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Authors | R Tomaszewska, A Dembiński, Z Warzecha, M Banaś, S J Konturek, J Stachura |
Journal | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
(J Physiol Pharmacol)
Vol. 43
Issue 4
Pg. 345-52
(Dec 1992)
ISSN: 0867-5910 [Print] Poland |
PMID | 1294265
(Publication Type: Journal Article)
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Chemical References |
- Isoquinolines
- Platelet Activating Factor
- Pyridinium Compounds
- Tetrahydroisoquinolines
- Ceruletide
- TCV 309
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Topics |
- Acute Disease
- Animals
- Ceruletide
(antagonists & inhibitors, toxicity)
- Isoquinolines
(pharmacology)
- Male
- Pancreas
(blood supply, pathology)
- Pancreatitis
(chemically induced, pathology, prevention & control)
- Platelet Activating Factor
(antagonists & inhibitors, toxicity)
- Pyridinium Compounds
(pharmacology)
- Rats
- Rats, Wistar
- Regional Blood Flow
(drug effects)
- Tetrahydroisoquinolines
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