Abstract |
The purpose of this study was to identify the optimal murine model for the study of peripheral nerve injury and nerve and limb transplantation. The degree of self-mutilation (autotomy) following sciatic and saphenous nerve injury was assessed in four mouse strains, Balb/C, C57BL/6J, C57BL/10J, and C3HEB, commonly used in surgical research. Experimental groups included sciatic and saphenous nerve transection with repair (n = 9) or without repair (n = 9), as well as housing arrangements favoring social interaction vs. isolation. Autotomy was most prevalent in the Balb/c and C3H strains at 56% and 89% overall, respectively, and was much less frequently seen in the C57Bl/10 and C57Bl/6 strains (22% and 11%, respectively). Autotomy was found to correlate most strongly with mouse strain, and with social contact as well. Two strains, C57BL/6J and C57BL/10J, were found to be highly resistant to self-mutilation, and are thus ideal animal models for peripheral-nerve and whole-limb transplant studies.
|
Authors | Roee E Rubinstein, Kenneth C Deem, John Jensen, Susan E MacKinnon, Thomas H Tung |
Journal | Microsurgery
(Microsurgery)
Vol. 23
Issue 4
Pg. 363-8
( 2003)
ISSN: 0738-1085 [Print] United States |
PMID | 12942528
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright 2003 Wiley-Liss, Inc. MICROSURGERY 23:363-368 2003 |
Topics |
- Animals
- Denervation
- Hindlimb
(innervation)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Peripheral Nerves
(surgery)
- Postoperative Period
- Sciatic Nerve
(surgery)
- Self Mutilation
- Social Environment
- Social Isolation
- Time Factors
|