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Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation.

Abstract
Neurotoxicity is a well-known side effect of tacrolimus-based immunosuppression after liver transplantation. Until now, only 31 cases of immunosuppression-associated leukoencephalopathy in liver transplant recipients reported in the literature are related to tacrolimus therapy. We report a patient who developed a posterior leukoencephalopathy syndrome, secondary to tacrolimus-based immunosuppression, after living donor liver transplantation. The special features of this case are the sudden and late onset of neurologic symptoms, a persistent comatose state, and increased signal intensity in follow-up MRI.
AuthorsNils R Frühauf, Susanne Koeppen Dagger, Fuat H Saner, Thomas Egelhof Dagger, Gregor Stavrou, Silvio Nadalin, Christoph E Broelsch
JournalLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (Liver Transpl) Vol. 9 Issue 9 Pg. 983-5 (Sep 2003) ISSN: 1527-6465 [Print] United States
PMID12942462 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Tacrolimus
Topics
  • Coma (etiology, pathology)
  • Female
  • Humans
  • Immunosuppressive Agents (administration & dosage)
  • Leukoencephalopathy, Progressive Multifocal (etiology, pathology)
  • Liver Transplantation
  • Living Donors
  • Magnetic Resonance Imaging
  • Middle Aged
  • Postoperative Complications
  • Tacrolimus (adverse effects)

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