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Innate and adaptive determinants of host susceptibility to medically important fungi.

Abstract
The host response is the outcome of an interplay between innate immunity, adaptive immunity (Th1, Th2, T regulatory cells, B cells and antibodies) and fungal virulence factors. Dendritic cells are the gatekeepers between innate and adaptive immunity and have been the intense focus of recent studies on innate immunity to fungi because of their ability to distinguish between different forms of a fungal species, to drive Th1 versus Th2 versus T regulatory responses, and potentially be modulated by fungal products. New mechanisms have been described by which anti-fungal antibodies can modulate infection and augment T cell immunity. Th1 responses are central to limiting infection with many fungi; thus, a great deal of attention has been focused recently on the antigen(s) that trigger such a response.
AuthorsGary B Huffnagle, George S Deepe
JournalCurrent opinion in microbiology (Curr Opin Microbiol) Vol. 6 Issue 4 Pg. 344-50 (Aug 2003) ISSN: 1369-5274 [Print] England
PMID12941402 (Publication Type: Journal Article, Review)
Chemical References
  • Antigens, Fungal
Topics
  • Animals
  • Antibody Formation (immunology)
  • Antigens, Fungal (immunology)
  • Disease Susceptibility (immunology)
  • Humans
  • Immunity, Cellular (immunology)
  • Mycoses (immunology)

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