Transsphenoidal hypophysectomy for four dogs with pituitary ACTH-producing adenoma.

Abstract

Four dogs diagnosed as pituitary-dependent hyperadrenocorticism were treated with transsphenoidal hypophysectomy and postoperative hormone supplementation therapy. On histological examination of the resected tissues, the tumors were ACTH-producing adenoma of the anterior lobe. Clinical signs such as alopecia and calcinosis cutis, as well as endocrinological abnormalities, were markedly alleviated after surgery. The clinical courses of these 4 dogs suggest that transsphenoidal hypophysectomy may be a useful treatment for pituitary-dependent hyperadrenocorticism.

• Authors: Yasushi Hara, Masahiro Tagawa, Hiroyuki Masuda, Toshinori Sako, Hidekazu Koyama, Hiromitsu Orima, Shinichiro Nakamura, Kimimasa Takahashi, Naoko Sanno, Akira Teramoto
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 65 Issue 7 Pg. 801-4 (Jul 2003) ISSN: 0916-7250 [Print] Japan
• PMID: 12939508 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adenoma (metabolism, pathology, surgery, veterinary)
• Adrenocorticotropic Hormone (metabolism)
• Animals
• Dog Diseases (metabolism, pathology, surgery)
• Dogs
• Female
• Hypophysectomy (methods, veterinary)
• Male
• Pituitary Gland (surgery)