[Effect of panaxatriol saponins isolated from Panax notoginseng (PTS) on myocardial ischemic arrhythmia in mice and rats].

Abstract

PTS, one of the major effective components of Panax notoginseng was found to exert remarked antiarrhythmic activities on coronary artery ligation induced ischemic and reperfused arrhythmias in rats. PTS also reduced the size of myocardial infarct. For i.v. CaCl2-Ach induced atrial fibrillation and/or flutter in mice, PTS produced a significant protective effect. In addition, PTS showed an action of prolonging the life under the condition of normobaric hypoxia.

• Authors: B Y Gao, X J Li, L Liu, B H Zhang
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 27 Issue 9 Pg. 641-4 ( 1992) ISSN: 0513-4870 [Print] China
• PMID: 1293932 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Ginsenosides
• Saponins
• Triterpenes
• panaxatriol

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (drug therapy, etiology)
• Atrial Fibrillation (prevention & control)
• Atrial Flutter (prevention & control)
• Female
• Ginsenosides
• Male
• Mice
• Myocardial Ischemia (complications)
• Myocardial Reperfusion Injury (complications)
• Rats
• Rats, Wistar
• Saponins (therapeutic use)
• Triterpenes (therapeutic use)