Effects of L-tetrahydropalmatine on energy metabolism, endothelin-1 and NO during acute cerebral ischemia-reperfusion of rats.

Abstract

To investigate the effects of L-tetrahydropalmatine (L-THP) on energy metabolism, endothelin-1 (ET-1) and NO during acute cerebral ischemia-reperfusion of rats, 24 Wistar rats were randomly divided into four groups, with 6 rats in each group: sham-operation group, simple ischemia group, ischemia-reperfusion group and treatment group (L-THP group). Cerebral ATP, lactate, ET-1 and NO levels were measured in all groups. Our results showed that treatment with L-THP could increase cerebral ATP levels, but decrease cerebral lactate, ET-1 and NO concentrations during ischemia-reperfusion in the treatment group. It is concluded that L-THP could improve cerebral energy metabolism and protect the injured brain tissue, the mechanism of which might be related to suppression of overproduction of ET-1 and NO.

• Authors: G Yang, P Wang, Y Tang, C Jiang, D Wang
• Journal: Journal of Tongji Medical University = Tong ji yi ke da xue xue bao (J Tongji Med Univ) Vol. 19 Issue 4 Pg. 285-7 ( 1999) ISSN: 0257-716X [Print] China
• PMID: 12938519 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Berberine Alkaloids
• Endothelin-1
• Nitric Oxide
• tetrahydropalmatine

Topics

• Animals
• Berberine Alkaloids (pharmacology)
• Brain Ischemia (metabolism)
• Case-Control Studies
• Endothelin-1 (metabolism)
• Energy Metabolism
• Nitric Oxide (metabolism)
• Rats
• Rats, Wistar
• Reperfusion Injury