[Renal protective effect of nilestriol in aged women with hypertension].

Abstract

OBJECTIVE:

To investigate the renal protective effect of nilestriol in aged hypertensive women.

METHODS:

Forty-one aged hypertensive women treated with antihypertensive drugs were randomly divided into two groups. The women in Group A (n = 21) received nilestriol, whereas those in Group B (n = 20) received a placebo for six months. Antihypertensive drugs were unchanged. Twenty-four healthy subjects were set as the normal control group.

RESULTS:

1. Before the treatment, the levels of urinary transferrin (TRF), retinol binding protein (RBP), P-selectin, vWF, and ET-1 were significantly higher in the aged hypertensive women than those in the control group. 2. The levels of TRF and RBP significantly decreased in both Group A and Group B after the 6-month treatment, but these levels in Group A were significantly lower than those in Group B (P < 0.05). 3. The levels of P-selectin, vWF, and ET-1 in Group A were significantly lower than those in Group B (P < 0.05-0.01) after the treatment.

CONCLUSION:

1. In aged hypertensive women treated with antihypertensive drugs, the renal function is still damaged; 2. Nilestriol can significantly decrease the levels of TRF and RBP; 3. The renal protective effect of nilestriol may be related to the protection of endothelin function and antithrombosis activity.

• Authors: Kan Yang, Hong-wei Pan, Wei-hong Jiang
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 28 Issue 1 Pg. 62-4 (Feb 28 2003) ISSN: 1000-5625 [Print] China
• PMID: 12934402 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• P-Selectin
• Retinol-Binding Proteins
• Transferrin
• nylestriol
• Quinestrol

Topics

• Aged
• Female
• Humans
• Hypertension (complications, drug therapy)
• Kidney Diseases (etiology, prevention & control)
• Male
• Middle Aged
• P-Selectin (urine)
• Postmenopause
• Quinestrol (analogs & derivatives, therapeutic use)
• Retinol-Binding Proteins (urine)
• Transferrin (urine)