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Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery.

Abstract
Micelles prepared from polyethylene glycols of various lengths conjugated with phosphatidylethanolamine (PEG-PE) were loaded with various poorly soluble anticancer agents. PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation.
AuthorsAnatoly N Lukyanov, Zhonggao Gao, Vladimir P Torchilin
JournalJournal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 91 Issue 1-2 Pg. 97-102 (Aug 28 2003) ISSN: 0168-3659 [Print] Netherlands
PMID12932641 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Excipients
  • Micelles
  • Phosphatidylethanolamines
  • Polyethylene Glycols
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, chemistry, pharmacokinetics)
  • Drug Delivery Systems
  • Enzyme-Linked Immunosorbent Assay
  • Excipients
  • Female
  • Mice
  • Mice, Inbred C57BL
  • Micelles
  • Neoplasms (drug therapy, pathology)
  • Particle Size
  • Phosphatidylethanolamines
  • Polyethylene Glycols
  • Solubility

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