Abstract | PURPOSE: To evaluate the use of percutaneous transcatheter thrombolysis in the treatment of thrombosis due to radial artery cannulation. METHODS AND RESULTS: Seven patients (4 women; age range 41-62 years) with symptomatic cannulation-induced thrombosis and failure to improve after systemic anticoagulation underwent 8 catheter-directed thrombolytic infusions at our institution over a 3-year period. Access was either antegrade through the brachial artery or retrograde through the femoral artery. Thrombolytic infusions with urokinase began 2 to 12 days (average 6) after removal of the radial artery catheter. The thrombolytic infusion was successful in 5 of 7 patients based on angiographic flow restoration with <20% residual thrombus and significant clinical improvement in the ischemia. CONCLUSIONS: When systemic anticoagulation has failed, percutaneous catheter-directed thrombolytic infusion appears to be effective in the treatment of most patients with severe ischemic hand symptoms due to thrombosis after radial artery cannulation.
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Authors | Jean-François H Geschwind, Mandeep S Dagli, Drew L Lambert, Hicham Kobeiter |
Journal | Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
(J Endovasc Ther)
Vol. 10
Issue 3
Pg. 590-4
(Jun 2003)
ISSN: 1526-6028 [Print] United States |
PMID | 12932173
(Publication Type: Journal Article)
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Chemical References |
- Plasminogen Activators
- Urokinase-Type Plasminogen Activator
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Topics |
- Adult
- Catheterization
(adverse effects)
- Female
- Hand
(blood supply)
- Humans
- Ischemia
(drug therapy, etiology)
- Male
- Middle Aged
- Plasminogen Activators
(therapeutic use)
- Radial Artery
- Retrospective Studies
- Thrombolytic Therapy
- Thrombosis
(drug therapy, etiology)
- Urokinase-Type Plasminogen Activator
(therapeutic use)
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