[Successful treatment with foscarnet for disseminated varicella-zoster infection after reduced intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma].

Abstract

Visceral disseminated varicella-zoster virus (VZV) infection occurred with acute graft-versus-host disease in a 33-year-old Japanese male with non-Hodgkin lymphoma who had undergone allogeneic stem cell transplantation from an HLA-identical sibling after reduced intensity conditioning chemotherapy. Although ganciclovir and acyclovir treatment was effective temporarily, the number of VZV-DNA copies in the blood remained at a high level, and the hepatitis was prolonged. The patient was treated with foscarnet, which led to improvement of the VZV viremia and the hepatic dysfunction. Foscarnet therapy should be considered for acyclovir-resistant VZV infection in the setting of allogeneic hematopoietic stem cell transplantation.

• Authors: Yasutaka Aoyama, Ryousuke Yamamura, Etsuko Shima, Hirohisa Nakamae, Kaori Makita, Taro Hasegawa, Chikahiko Sakamoto, Yoshiki Terada, Genzyu Kho, Kensuke Ohta, Takahisa Yamane, Takayuki Takubo, Masayuki Hino
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 44 Issue 7 Pg. 451-5 (Jul 2003) ISSN: 0485-1439 [Print] Japan
• PMID: 12931563 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Foscarnet
• Acyclovir

Topics

• Acyclovir (pharmacology)
• Adult
• Antiviral Agents (therapeutic use)
• Central Nervous System Neoplasms (complications, therapy)
• Drug Resistance, Viral
• Foscarnet (therapeutic use)
• Graft vs Host Disease (immunology)
• Hematopoietic Stem Cell Transplantation (methods)
• Herpes Zoster (drug therapy, etiology)
• Humans
• Lymphoma, Non-Hodgkin (complications, therapy)
• Male
• Recurrence
• Transplantation, Homologous