Tolterodine is equally effective in patients with mixed incontinence and those with urge incontinence alone.

Abstract

OBJECTIVE:

To examine the efficacy of tolterodine, an antimuscarinic agent with a bladder-selective profile, in patients with mixed incontinence (MI, stress and urge) compared with patients with urge incontinence (UI) alone.

PATIENTS AND METHODS:

The study included 239 patients with MI (urge predominating) and 755 with urge incontinence alone from a single-blind, multicentre trial of 1380 patients (80% female) with an overactive bladder. Those completing the trial were analysed 'per-protocol'. After a 7-day washout and a 3-day run-in to collect baseline information, patients were treated with tolterodine twice daily for 16 weeks. The two groups were compared for incontinence episodes/24 h, voiding frequency, nocturia episodes and pad usage after 16 weeks of treatment.

RESULTS:

After 16 weeks the median changes from baseline for all voiding variables were statistically significant for the MI and the UI groups (P < 0.001), with no apparent significant between-group differences. The median percentage reduction in incontinence episodes from baseline was 67% for the MI and 75% for the UI groups (P = 0.39). 'Dry' rates for the MI and UI groups at the end of the study were 39% (66/171) and 44% (243/552), respectively, whilst 24% of patients in each group (MI 40/170; UI 130/551) achieved a voiding pattern of < 8 voids/24 h. 'Cure' rates for nocturia and the reduction in the number of patients not using pads used were also similar between the groups.

CONCLUSION:

Tolterodine is as effective in reducing leakage and other symptoms of an overactive bladder in patients with MI as it is in patients with UI alone.

• Authors: K J Kreder Jr, L Brubaker, T Mainprize
• Journal: BJU international (BJU Int) Vol. 92 Issue 4 Pg. 418-21 (Sep 2003) ISSN: 1464-4096 [Print] England
• PMID: 12930432 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Benzhydryl Compounds
• Cresols
• Muscarinic Antagonists
• Phenylpropanolamine
• Tolterodine Tartrate

Topics

• Adult
• Aged
• Aged, 80 and over
• Benzhydryl Compounds (therapeutic use)
• Cohort Studies
• Cresols (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Muscarinic Antagonists (therapeutic use)
• Phenylpropanolamine
• Single-Blind Method
• Tolterodine Tartrate
• Treatment Outcome
• Urinary Incontinence (drug therapy)
• Urinary Incontinence, Stress (drug therapy)
• Urination (drug effects)