Neuroimaging of serotonin transporters in post-stroke pathological crying.

Abstract

Pathological crying (PC) is a neuropsychiatric disorder characterized by an excessive tendency towards crying after brain damage. To elucidate the role of serotonin neurotransmission for PC, a pilot study was performed using single photon emission computed tomography with [123I]beta-CIT to estimate central (midbrain/pons and thalamus/hypothalamus) serotonin transporter (SERT) densities in 15 stroke patients who did or did not have PC. SERT binding ratios in midbrain/pons were significantly lower in the PC subgroup.

• Authors: Toshiya Murai, Henryk Barthel, Jörg Berrouschot, Dietlind Sorger, D Yves von Cramon, Ulrich Müller
• Journal: Psychiatry research (Psychiatry Res) Vol. 123 Issue 3 Pg. 207-11 (Jul 30 2003) ISSN: 0165-1781 [Print] Ireland
• PMID: 12928109 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• Membrane Glycoproteins
• Membrane Transport Proteins
• Nerve Tissue Proteins
• Radiopharmaceuticals
• SLC6A4 protein, human
• Serotonin Plasma Membrane Transport Proteins
• 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
• Cocaine

Topics

• Brain (metabolism, pathology)
• Carrier Proteins (metabolism)
• Cocaine (analogs & derivatives)
• Crying (psychology)
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Membrane Glycoproteins (metabolism)
• Membrane Transport Proteins
• Middle Aged
• Nerve Tissue Proteins
• Pilot Projects
• Radiopharmaceuticals
• Serotonin Plasma Membrane Transport Proteins
• Stroke (metabolism, pathology)
• Time Factors
• Tomography, Emission-Computed, Single-Photon