Abstract | OBJECTIVE: METHODS: RESULTS: Significant increases in geometric mean serum IgG against all antigens occurred in non-vaccinated children, but more children responded against pertussis toxin and FHA than against pertactin (96%, 97%, and 62%, respectively). Of the children who had pertussis even though they were vaccinated with the pertussis toxoid vaccine, 97% responded to FHA, while responses to pertussis toxin and pertactin were less common (68% and 61%, respectively). In the 20 adults, the proportions of responders to FHA, pertussis toxin and pertactin were 90%, 80% and 55%, respectively. CONCLUSION: Determination of IgG against pertussis toxin and FHA in paired sera in non-vaccinated children with pertussis is a more sensitive diagnostic tool than determination of IgG against pertactin. Pertactin IgG determinations might be of value as a complement to the other antibody assays in vaccinated children and in adults.
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Authors | B Trollfors, T Lagergård, E Gunnarsson, J Taranger |
Journal | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
(Clin Microbiol Infect)
Vol. 9
Issue 7
Pg. 585-9
(Jul 2003)
ISSN: 1198-743X [Print] England |
PMID | 12925096
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Adhesins, Bacterial
- Bacterial Outer Membrane Proteins
- Hemagglutinins
- Immunoglobulin G
- Vaccines, Acellular
- Virulence Factors, Bordetella
- filamentous hemagglutinin adhesin, Bordetella pertussis
- pertactin
- Pertussis Toxin
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Topics |
- Adhesins, Bacterial
(immunology)
- Adult
- Bacterial Outer Membrane Proteins
(immunology)
- Child, Preschool
- Female
- Hemagglutinins
(immunology)
- Humans
- Immunoglobulin G
(analysis, immunology)
- Infant
- Male
- Middle Aged
- Pertussis Toxin
(immunology)
- Vaccines, Acellular
(immunology)
- Virulence Factors, Bordetella
(immunology)
- Whooping Cough
(diagnosis, immunology)
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