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Thrombopoietin-producing hepatocellular carcinoma.

Abstract
A 66-year-old man with hepatocellular carcinoma (HCC) showed marked thrombocytosis (110.7 x 10(4)/microl). Bone marrow (BM) aspirates demonstrated an increase of mature megakaryocytes (MgK). The serum thrombopoietin (TPO) level was increased to about 100-fold that of the normal level in the terminal stage. However, the platelet count gradually decreased to 13.5 x 10(4)/microl. The autopsy specimen revealed normoplastic BM with decreased MgK, mainly consisting of the immature type, and it was negative for tumor cells. Liver specimen showed markedly fatty metamorphosis. Immunohistochemical staining of TPO demonstrated that hepatocytes were weakly stained and HCC cells strongly stained, suggesting TPO-producing HCC.
AuthorsTomiko Ryu, Satoshi Nishimura, Hideaki Miura, Haruki Yamada, Haruhiko Morita, Hiroshi Miyazaki, Shigehiro Kitamura, Yasusada Miura, Toshikazu Saito
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 42 Issue 8 Pg. 730-4 (Aug 2003) ISSN: 0918-2918 [Print] Japan
PMID12924502 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Thrombopoietin
Topics
  • Aged
  • Carcinoma, Hepatocellular (metabolism, pathology)
  • Humans
  • Liver Neoplasms (metabolism, pathology)
  • Male
  • Thrombocytopenia (immunology)
  • Thrombocytosis (chemically induced)
  • Thrombopoietin (adverse effects, metabolism)

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