[The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia].

Abstract

The results of experiments on cats and dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, exceeds the structural precursors (trimecaine and lidocaine), as well as the reference drugs quinidine and propranolol, in intensity of the antiarrhythmic action upon single administration on the occlusive and reperfusive arrhythmia models. The therapeutic effect of quaternidine in animals with acute myocardial ischemia lasts for about 8 h, which more than 20 times longer as compared to the duration of action of both lidocaine and trimecaine.

• Authors: Ia V Kostin, D S Blinov, I Ia Moiseeva
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2003 May-Jun Vol. 66 Issue 3 Pg. 29-31 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Protivoaritmicheskaia aktivnost' ammonievogo proizvodnogo trimekaina na fone ishemicheskogo povrezhdeniia serdtsa.
• PMID: 12924229 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Quaternary Ammonium Compounds
• Trimecaine

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Arrhythmias, Cardiac (etiology, prevention & control)
• Cats
• Dogs
• Myocardial Ischemia (complications)
• Quaternary Ammonium Compounds (pharmacology)
• Trimecaine (analogs & derivatives, pharmacology)