Post-cholecystectomy alkaline reactive gastritis: a randomized trial comparing sucralfate versus rabeprazole or no treatment.

At present there are no well-established pharmacological approaches in the management of post-cholecystectomy alkaline reactive gastritis. The aim of this study was to assess the effect of sucralfate versus rabeprazole or no treatment on dyspeptic symptoms and endoscopic/histological signs in a population of patients with a history of cholecystectomy and evidence of alkaline reactive gastritis.
Sixty dyspeptic patients fulfilling the following criteria of inclusion took part in this study: (1) a history of cholecystectomy; (2) no use of anti-inflammatory steroidal and non-steroidal drugs, or abuse of alcohol; (3) evidence of abundant gastric bile reflux at endoscopy; (4) endoscopic signs of chronic gastritis; (5) histological signs of chronic gastritis; and (6) absence of Helicobacter pylori infection. Dyspeptic symptoms were evaluated by means of a self-administered validated questionnaire. Patients included in the study were randomly assigned to one of three treatment groups for 3 months: sucralfate, rabeprazole, observation. Patients were re-evaluated at the end of the treatment.
Sucralfate and rabeprazole therapies were both able to significantly reduce epigastric pain, heartburn, bloating and halitosis. Endoscopic/histological signs were lower in both treatment groups compared to the observation group.
Both sucralfate and rabeprazole therapies are effective treatment options in the patients with alkaline gastritis when compared with observation.
AuthorsLuca Santarelli, Maurizio Gabrielli, Marcello Candelli, Filippo Cremonini, Enrico C Nista, Giovanni Cammarota, Giovanni Gasbarrini, Antonio Gasbarrini
JournalEuropean journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 15 Issue 9 Pg. 975-9 (Sep 2003) ISSN: 0954-691X [Print] England
PMID12923369 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Rabeprazole
  • Sucralfate
  • Omeprazole
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adult
  • Aged
  • Analysis of Variance
  • Anti-Ulcer Agents (therapeutic use)
  • Benzimidazoles (therapeutic use)
  • Cholecystectomy (adverse effects)
  • Duodenogastric Reflux (complications)
  • Dyspepsia (drug therapy, etiology)
  • Female
  • Gastritis (drug therapy, etiology, pathology)
  • Gastroscopy
  • Humans
  • Male
  • Middle Aged
  • Omeprazole (analogs & derivatives)
  • Pilot Projects
  • Rabeprazole
  • Statistics, Nonparametric
  • Sucralfate (therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: