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Post-cholecystectomy alkaline reactive gastritis: a randomized trial comparing sucralfate versus rabeprazole or no treatment.

AbstractOBJECTIVE:
At present there are no well-established pharmacological approaches in the management of post-cholecystectomy alkaline reactive gastritis. The aim of this study was to assess the effect of sucralfate versus rabeprazole or no treatment on dyspeptic symptoms and endoscopic/histological signs in a population of patients with a history of cholecystectomy and evidence of alkaline reactive gastritis.
METHODS:
Sixty dyspeptic patients fulfilling the following criteria of inclusion took part in this study: (1) a history of cholecystectomy; (2) no use of anti-inflammatory steroidal and non-steroidal drugs, or abuse of alcohol; (3) evidence of abundant gastric bile reflux at endoscopy; (4) endoscopic signs of chronic gastritis; (5) histological signs of chronic gastritis; and (6) absence of Helicobacter pylori infection. Dyspeptic symptoms were evaluated by means of a self-administered validated questionnaire. Patients included in the study were randomly assigned to one of three treatment groups for 3 months: sucralfate, rabeprazole, observation. Patients were re-evaluated at the end of the treatment.
RESULTS:
Sucralfate and rabeprazole therapies were both able to significantly reduce epigastric pain, heartburn, bloating and halitosis. Endoscopic/histological signs were lower in both treatment groups compared to the observation group.
CONCLUSION:
Both sucralfate and rabeprazole therapies are effective treatment options in the patients with alkaline gastritis when compared with observation.
AuthorsLuca Santarelli, Maurizio Gabrielli, Marcello Candelli, Filippo Cremonini, Enrico C Nista, Giovanni Cammarota, Giovanni Gasbarrini, Antonio Gasbarrini
JournalEuropean journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 15 Issue 9 Pg. 975-9 (Sep 2003) ISSN: 0954-691X [Print] England
PMID12923369 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Rabeprazole
  • Sucralfate
  • Omeprazole
Topics
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adult
  • Aged
  • Analysis of Variance
  • Anti-Ulcer Agents (therapeutic use)
  • Benzimidazoles (therapeutic use)
  • Cholecystectomy (adverse effects)
  • Duodenogastric Reflux (complications)
  • Dyspepsia (drug therapy, etiology)
  • Female
  • Gastritis (drug therapy, etiology, pathology)
  • Gastroscopy
  • Humans
  • Male
  • Middle Aged
  • Omeprazole (analogs & derivatives)
  • Pilot Projects
  • Rabeprazole
  • Statistics, Nonparametric
  • Sucralfate (therapeutic use)
  • Treatment Outcome

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