[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)].

Abstract

The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.

• Authors: S A Shalimov, E P Trokhimenko, I V Dziublik, L V Keĭsevich, I I Volchenskova, G I Kogut, G T Glukhen'kaia
• Journal: Likars'ka sprava (Lik Sprava) 1992 Nov-Dec Issue 11-12 Pg. 114-7 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Doklinicheskie ispytaniia poliplatillena, protivoopukholevaia aktivnost' kompleksnogo soedineniia platiny s DNK na modeli leĭkemii P-388 v kul'ture kletok HEp-2 (soobshchenie 1).
• PMID: 1292205 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• DNA Adducts
• cisplatin-DNA adduct
• DNA
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Cisplatin (therapeutic use)
• DNA (therapeutic use)
• DNA Adducts
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Humans
• Leukemia P388 (drug therapy)
• Mice
• Mice, Inbred DBA
• Neoplasm Transplantation
• Time Factors
• Tumor Cells, Cultured (drug effects)