Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis.

Abstract	The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles. SR-BI is abundantly expressed in several tissues, including the liver, where its expression is regulated by various mechanisms, including the transcriptional activity of nuclear receptors. The importance of SR-BI in overall HDL cholesterol metabolism and its antiatherogenic activity in vivo has been definitively established by SR-BI gene manipulation in mice. Remarkably, SR-BI/apolipoprotein E double-knockout mice develop complex coronary artery disease, myocardial infarction, and heart failure. Additional studies should help to define the importance of SR-BI in human health and disease.
Authors	Bernardo L Trigatti, Monty Krieger, Attilio Rigotti
Journal	Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 23 Issue 10 Pg. 1732-8 (Oct 01 2003) ISSN: 1524-4636 [Electronic] United States
PMID	12920050 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References	CD36 Antigens Carrier Proteins Lipoproteins Lipoproteins, HDL Membrane Proteins RNA-Binding Proteins Receptors, Immunologic Receptors, Lipoprotein Receptors, Scavenger Scarb1 protein, mouse Scavenger Receptors, Class B high density lipoprotein receptors high density lipoprotein binding protein Cholesterol
Topics	Animals Arteriosclerosis (metabolism, prevention & control) Biological Transport CD36 Antigens (genetics, metabolism) Carrier Proteins Cells, Cultured Cholesterol (metabolism) Gene Expression Regulation Heart Diseases (genetics, metabolism) Lipoproteins (metabolism) Lipoproteins, HDL Liver (metabolism) Membrane Proteins Mice Mice, Knockout Protein Binding RNA-Binding Proteins Receptors, Immunologic Receptors, Lipoprotein (metabolism) Receptors, Scavenger Scavenger Receptors, Class B

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