[Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults].

Abstract

OBJECTIVE:

To study the diagnostic values of detection of glutamic acid decarboxylase antibody (GAD-Ab) for latent autoimmune diabetes in adults (LADA).

METHOD:

The clinical characteristics, body mass index (BMI), serum C-peptide levels, and HbAIC were compared between the 12 type 2 diabetic patients positive and 86 negative for GAD-Ab.

RESULTS:

The mean age, BMI, fasting and postprandial 2 h C-peptide levels in GAD-Ab-positive group were lower than those of GAD-Ab-negative group. The frequency of insulin use and prevalence of ketosis were higher in GAD-Ab-positive group than in GAD-Ab-negative group.

CONCLUSIONS:

The diagnosis of LADA can be established according to GAD-Ab-positivity, clinical characteristics and islet function. Patients with LADA should receive insulin therapy as early as possible to protect the residue islet B cells, reduce the occurrence of ketosis, and prevent diabetic complications of the eye, kidney and nerves.

• Authors: Yu-yu Huang, Ping Huang, Hui-ling Lou
• Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 23 Issue 8 Pg. 868-9 (Aug 2003) ISSN: 1000-2588 [Print] China
• PMID: 12919925 (Publication Type: English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Glutamate Decarboxylase

Topics

• Adult
• Aged
• Autoantibodies (blood)
• Diabetes Mellitus, Type 1 (diagnosis, immunology)
• Female
• Glutamate Decarboxylase (immunology)
• Humans
• Male
• Middle Aged