Abstract | BACKGROUND: METHODS: Families in whom both parents had proven IGE were ascertained through a multiplex families database. Clinical information including EEG recordings and detailed pedigrees was obtained. RESULTS: CONCLUSIONS: The clinical phenotype of affected offspring suggested that their epilepsy could be due to the combination of a putative "double dose" of genes from both sides of the family. In such families, as epilepsy genes could be inherited from both parents, a high risk of epilepsy in the offspring could be expected.
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Authors | Carla Marini, A Simon Harvey, James T Pelekanos, Samuel F Berkovic |
Journal | Epilepsia
(Epilepsia)
Vol. 44
Issue 9
Pg. 1250-4
(Sep 2003)
ISSN: 0013-9580 [Print] United States |
PMID | 12919400
(Publication Type: Journal Article)
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Topics |
- Adult
- Child
- Child, Preschool
- Electroencephalography
(methods)
- Epilepsy, Generalized
(genetics, physiopathology)
- Female
- Humans
- Male
- Pedigree
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