Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma.

Abstract

AIM:

To demonstrate whether class I MHC molecule, transporter associated with antigen processing (TAP), and heat-shock proteion70 (HSP70) expressed in liver cancer cells before the design and construction of CTL vaccine against hepatocellular carcinoma (HCC).

METHODS:

We studied 30 HCC specimens by labeled streptavidin biotin (LSAB) method of immunohistochemistry.

RESULTS:

The results showed that the majority of HCC cells investigated naturally expressed class I MHC and TAP, which were different from other tumor cells. Furthermore, we found that HSP70 expressed not only in cellular cytoplasm, but also on the cell surface in HCC.

CONCLUSION:

Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved. It is important to design and construct CTL vaccine against HCC.

• Authors: Xiao-Ling Deng, Wei Chen, Mei-Ying Cai, Da-Peng Wei
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 9 Issue 8 Pg. 1853-5 (Aug 2003) ISSN: 1007-9327 [Print] United States
• PMID: 12918137 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ATP-Binding Cassette Transporters
• HSP70 Heat-Shock Proteins
• Histocompatibility Antigens Class I
• transporter associated with antigen processing (TAP)

Topics

• ATP-Binding Cassette Transporters
• Carcinoma, Hepatocellular (metabolism)
• HSP70 Heat-Shock Proteins (metabolism)
• Histocompatibility Antigens Class I (metabolism)
• Humans
• Immunohistochemistry
• Liver Neoplasms (metabolism)