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Efficacy of vitamin E, phosphatidyl choline and pyruvate on Abeta neurotoxicity in culture.

Abstract
Oxidative stress is a pivotal factor in neuronal degeneration including that induced by exposure to amyloid-beta (Abeta). Treatment with antioxidants such as vitamin E can alleviate Abeta neurotoxicity. However, vitamin E was only marginally effective in clinical trials in Alzheimer's disease. Recent studies indicate that treatment with vitamin E (as a-tocopherol), sodium pyruvate and phosphatidyl choline (PC) is more effective than vitamin E alone against neuronal oxidative stress. We demonstrate herein that treatment of cultured murine cortical neurons with these 3 agents is also more effective than vitamin E alone against Abeta neurotoxicity as assayed by generation of reactive oxygen species and increased levels of phospho-isoforms of the microtubule-associated protein tau. These data underscore the potential efficacy of a combinatorial neuroprotective formulation against Abeta neurotoxicity.
AuthorsT B Shea, F J Ekinci, D Ortiz, T O Wilson, R J Nicolosi
JournalThe journal of nutrition, health & aging (J Nutr Health Aging) Vol. 7 Issue 4 Pg. 252-5 ( 2003) ISSN: 1279-7707 [Print] France
PMID12917750 (Publication Type: Journal Article)
Chemical References
  • Amyloid beta-Peptides
  • Antioxidants
  • Neuroprotective Agents
  • Phosphatidylcholines
  • Pyruvates
  • Vitamin E
Topics
  • Amyloid beta-Peptides (adverse effects)
  • Animals
  • Antioxidants (pharmacology)
  • Cells, Cultured
  • Drug Synergism
  • Mice
  • Neurons (drug effects)
  • Neuroprotective Agents (pharmacology)
  • Organisms, Genetically Modified
  • Oxidative Stress (drug effects)
  • Phosphatidylcholines (pharmacology)
  • Pyruvates (pharmacology)
  • Vitamin E (pharmacology)

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