Topical cyclosporine A 0.5% as a possible new treatment for superior limbic keratoconjunctivitis.

Abstract

PURPOSE:

To report the early success of the use of topical cyclosporine A 0.5% drops to treat Theodore's superior limbic keratoconjunctivitis (SLK).

DESIGN:

A retrospective noncomparative case series.

PARTICIPANTS:

Five patients diagnosed with SLK.

INTERVENTION:

All five patients were treated with topical cyclosporine A 0.5% drops as primary or adjunctive therapy after treatment failure in some of prednisolone acetate 1% drops and topical silver nitrate 0.5% application. Topical cyclosporine A 0.5% drops were used four times a day in both eyes.

MAIN OUTCOME MEASURES:

Resolution of symptoms (foreign body sensation and irritation) and signs (rose bengal staining, tarsal papillary reaction, and injection).

RESULTS:

All five patients had long-term (6 months to 3 years) improvement of irritation and foreign body sensation, as well as improvement of injection and filamentary keratitis. Aside from burning on instillation, there were no complications related to this therapy.

CONCLUSIONS:

Topical cyclosporine A 0.5% is helpful as primary or adjunctive therapy for SLK. It may also be used as a maintenance drug to prevent recurrence. Further study may delineate the specific role and treatment parameters for the use of topical cyclosporine A 0.5% in the treatment of SLK.

• Authors: Henry D Perry, Sima Doshi-Carnevale, Eric D Donnenfeld, Howard S Kornstein
• Journal: Ophthalmology (Ophthalmology) Vol. 110 Issue 8 Pg. 1578-81 (Aug 2003) ISSN: 0161-6420 [Print] United States
• PMID: 12917176 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine
• prednisolone acetate
• Silver Nitrate
• Prednisolone

Topics

• Administration, Topical
• Adult
• Cyclosporine (administration & dosage, therapeutic use)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Keratoconjunctivitis (drug therapy)
• Limbus Corneae
• Middle Aged
• Prednisolone (administration & dosage, analogs & derivatives, therapeutic use)
• Retrospective Studies
• Silver Nitrate (administration & dosage, therapeutic use)
• Treatment Failure