Abstract | BACKGROUND AND PURPOSE: METHODS: Fifty patients with sporadic small vessel disease and 19 patients with CADASIL underwent diffusion-weighted imaging. All had been asymptomatic for 3 months before imaging. Diffusion-weighted images were screened by two raters for new lesions; lesions were confirmed as recent by a visible reduction of diffusivity on the corresponding apparent diffusion coefficient maps. RESULTS: Recent ischemic lesions were identified in four patients with sporadic small vessel disease (8.0%) and two patients with CADASIL (10.5%). CONCLUSION: Asymptomatic new lesions are found in cases of sporadic small vessel disease and CADASIL. The frequency of new lesions suggests that this approach has a potential role as a surrogate marker in therapeutic trials that warrants further investigation.
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Authors | Michael O'Sullivan, Philip M Rich, Thomas R Barrick, Christopher A Clark, Hugh S Markus |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 24
Issue 7
Pg. 1348-54
(Aug 2003)
ISSN: 0195-6108 [Print] United States |
PMID | 12917126
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Brain Infarction
(diagnosis, epidemiology)
- Brain Ischemia
(diagnosis, epidemiology)
- Cerebral Arterial Diseases
(diagnosis, genetics)
- Cerebral Infarction
(diagnosis, epidemiology)
- Cohort Studies
- Dementia, Multi-Infarct
(diagnosis, epidemiology)
- Dementia, Vascular
(diagnosis, epidemiology)
- Diffusion Magnetic Resonance Imaging
- Dystonic Disorders
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Prevalence
- United Kingdom
(epidemiology)
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