The long-term use of cyproterone acetate in pedophilia: a case study.

This investigation reports the long-term use of the antiandrogen cyproterone acetate (CPA) in a pedophile, who was studied continuously over 38 months. Measures of sexual arousal, serum testosterone, and gonadotropin levels were significantly reduced by the drug as compared with placebo and no treatment; prolactin levels were significantly elevated. Some workers have observed that long-term administration of CPA (more than one year, which was then discontinued) produced enduring (in some cases apparently permanent) anti-libidinal effects; however, in the case described, within three weeks of stopping the drug, all measures had returned to pretrial levels. The importance of continuous long-term monitoring in sex offenders receiving an antiandrogen is discussed.
AuthorsA J Cooper, Z Cernovsky, R V Magnus
JournalJournal of sex & marital therapy (J Sex Marital Ther) Vol. 18 Issue 4 Pg. 292-302 ( 1992) ISSN: 0092-623X [Print] UNITED STATES
PMID1291700 (Publication Type: Case Reports, Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Gonadotropins, Pituitary
  • Testosterone
  • Cyproterone Acetate
  • Adult
  • Cyproterone Acetate (administration & dosage, pharmacology, therapeutic use)
  • Gonadotropins, Pituitary (blood)
  • Humans
  • Libido (drug effects)
  • Male
  • Pedophilia (blood, drug therapy)
  • Penile Erection (drug effects)
  • Testosterone (blood)
  • Time Factors

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